Sedative and analgesic effects of remifentanil combined with prapofol administered by TCI versus intravenous infusion during local anesthesia
10.3760/cma.j.issn.0254-1416.2012.05.030
- VernacularTitle:靶控输注与静脉输注瑞芬太尼复合异丙酚用于局部麻醉患者镇静镇痛术效应的比较
- Author:
Xiaowen LIU
;
Xiaoming DENG
;
Ye WANG
;
Lei WANG
;
Jinghu SUI
;
Yulei SUN
- Publication Type:Journal Article
- Keywords:
Analgesics,opioid;
Propofol;
Drug delivery systems;
Consscious sedation;
Analgesia
- From:
Chinese Journal of Anesthesiology
2012;32(5):622-625
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the sedative and analgesic effects of remifentanil combined with propofol administered by target-controlled infusion(TCI)and intravenous infusion during local anesthesia.Methods Sixty ASA Ⅰ or Ⅱ patients,aged 18-55 yr,with body mass index ＜ 30 kg/m2,scheduled for plastic surgery under local anesthesia,were equally and randomly divided into TCI group(group T)and intravenous infusion group (group V).Remifentanil(the initial target plasma concentration 1.0 ng/ml)and propofol(the initial target plasma concentration 1.0 ng/ml)were given by TCI before local anesthesia in group T.Remifentanil was infused at a rate of 0.05 μg·kg-1 ·min-1 after a loading dose of 0.25 μg/kg and propofol was infused at a rate of 3 mg·kg-1 ·h-1 after a loading dose of 0.5 mg/kg in group V.The target plasma concentration or infusion rate was adjusted to maintain the modified OAA/S score of 2 or 3.Hypoxemia,bradypnea and/or apnea were recorded during operation.The total amount of remifentanil and propofol consumed was calculated.Results Compared with group V,the incidence of hypoxemia,bradypnea and/or apnea were significantly decreased during operation,and the total amount of remifentanil and propofol consumed was significantly reduced in group T(P ＜ 0.05).Conclusion The sedative and analgesic effects of remifentanil combined with propofol given by TCI are superior to those given by intravenous infusion during local anesthesia,with better safety.
