Progress of prenatal infection and preterm bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2012.04.004
- VernacularTitle:产前感染和炎症与早产儿支气管肺发育不良的关系
- Author:
Haixia WANG
- Publication Type:Journal Article
- Keywords:
Intra-uterine infection;
Inflammation;
Cytokines;
Preterm;
Bronchopulmonary dysplasia
- From:
International Journal of Pediatrics
2012;39(4):337-341
- CountryChina
- Language:Chinese
-
Abstract:
In recent years a body of data has accumulated,linking preterm bronchopulmonary dysplasia (BPD) to prenatal infections and inflammations.The lungs of preterms are still in development.Fetal lungs with intrauterine infections are exposed to high levels of inflammation factors ahead of time,which does harms to lungs.The immune systems of preterms are so immature that they can not effectively down-regulate and control the inflammation process,which exaggerates the inflammation process and causes the abnormal levels of some important growth factors during lung development.As a result,the lung undergoes an dysmorphic microvasculature and disrupted alveolarization,which leads to BPD eventually because of the stagnancy of lung developing.
