Progress of biological mechanisms of astrocyte in epilepsy
10.3760/cma.j.issn.1673-4408.2012.04.013
- VernacularTitle:星形胶质在癫(癎)中的生物学机制研究进展
- Author:
Ying LUAN
- Publication Type:Journal Article
- Keywords:
Astrocyte;
Epilepsy;
Gap junction;
Glutamate;
Ion channel
- From:
International Journal of Pediatrics
2012;39(4):369-371
- CountryChina
- Language:Chinese
-
Abstract:
Many studies have shown that changes in ion channels,abnormal regulation of neurotransmitters and their receptors,blood-brain barrier damage,inflammation,oxidative stress etc,are all related with seizures.Animal models of epilepsy,focusing on autopsy of patients with epilepsy or pathological changes of epileptic,have found that there is a certain relationship between astrocytes and epilepsy,but the cause has remained unclear.At present,most of antiepilepfic drugs work on the target of neurons,which have certain impact on the patient's congnitive and brain function.Therefore,to investigate the pathogenesis of epilepsy from the perspective of astcytes,it might help to identify new intervention targets for new antiepileptic drugs.
