The regulatory roles of microRNA in epilepsy
10.3760/cma.j.issn.1673-4408.2012.04.014
- VernacularTitle:微小RNA在癫(癎)中的调节作用
- Author:
Huimei XIAO
- Publication Type:Journal Article
- Keywords:
MicroRNA;
Nervous disease;
Epilepsy
- From:
International Journal of Pediatrics
2012;39(4):372-375
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA,a type of small non-coding RNA specialized in regulation of gene expression,extensively participates in biological cell development,differentiation apoptosis and other cellular processes.Studies have shown that microRNA plays vital regulatory roles in epilepsy.Its mechanisms include regulation of inflammatory responses,proliferation of glial cells,the reconstruction of the synaptic contact and pro-apoptotic gene expression.This article reviews the molecular mechanisms of microRNA in regulation of epilepsy and the possible regulatory roles of microRNA in other nervous diseases.
