The relationship of multi-drug resistance associated protein and refractory epilepsy
10.3760/cma.j.issn.1673-4408.2012.04.016
- VernacularTitle:多药耐药相关蛋白与难治性癫(癎)发病关系的研究进展
- Author:
Xuan YUE
- Publication Type:Journal Article
- Keywords:
Multi-drug resistance associated protein;
Refractory epilepsy;
Antiepileptic drugs
- From:
International Journal of Pediatrics
2012;39(4):377-379
- CountryChina
- Language:Chinese
-
Abstract:
The mechanism of drug resistance of refractory epilepsy has remained unclear.In recent years,studies have shown that the multi-drug resistance associated protein(MRP) is related with refractory epilepsy.The mechanism responsible for the drug resistance may have something to do with the higher expression of MRP1 mRNA in brain tissues of refractory epilepsy patients.Through the use of drugs in cells to cells from the pump,it can reduce the drug concentration in brain and make the creation bears the medicine and inhibitors specific for MRP,which can significantly improve the effect of some antiepileptic drugs.Thus,further studies may provide new ways for the treatment of refractory epilepsy and find targets for new antiepileptic drugs.
