Association between the drug-metabolizing enzyme gene polymorphisms and toxicity of methotrexate in childhood acute lymphoblastic leukemia
10.3760/cma.j.issn.1673-4408.2012.03.018
- VernacularTitle:药物代谢酶基因多态性与甲氨蝶呤治疗儿童急性淋巴细胞白血病不良反应
- Author:
Hong LI
- Publication Type:Journal Article
- Keywords:
Gene polymorphism;
Acute lymphoblastic leukemia;
Methotrexate;
Toxicity;
Children
- From:
International Journal of Pediatrics
2012;39(3):274-276
- CountryChina
- Language:Chinese
-
Abstract:
With advances on drug genomics of leukemia,the drug toxicity has been found to be associated with the drug metabolism gene polymorphisms in children with acute lymphoblastic leukemia.Current researches are to focuse on how to find a genotype to predict methotrexate toxicity effectively and treat patients individually.This review illustrates the association between three drug-metabolizing enzyme gene polymorphisms including methylenetetrahydrofolate reductase,reduced folate carrer and glutathione S-transferase and toxicity of methotrexate.
