Advancement of Th17 cells in bronchopulmonary dysplasia
10.3760/cma.j.issn.1673-4408.2012.04.006
- VernacularTitle:Th17细胞在支气管肺发育不良疾病中的研究进展
- Author:
Yanjuan WANG
- Publication Type:Journal Article
- Keywords:
Th17;
Interleukin-17;
Bronchopulmonary dysplasia
- From:
International Journal of Pediatrics
2012;39(4):345-348
- CountryChina
- Language:Chinese
-
Abstract:
T helper 17 cells(Th17) are a recently discovered CD4+ T cells subsets,a new member of the Th1,Th2 family.Recent studies have found that IL-17 produced by Th17 can induce bronchial epithelial cells,endothelial cells and fibroblasts secreting IL-6,IL-8,ranulocyte colony-stimulating factor and tumor necrosis factor alpha and other cytokines,and promot recruitment of neutrophils in lung.Present studies show that th17plays an important role in the bronchopulmonary dysplasia incidence mechanism,and provides a new research direction in the prevention and treatment.
