Changes of renal histology of normobaric hyperoxia in neonatal rats

VernacularTitle:高氧对新生鼠肾组织损伤的病理改变
Author: Dong AN ; Hong JIANG
Publication Type:Journal Article
Keywords: Hyperoxia; Kidney; Neonatal rats
From: International Journal of Pediatrics 2012;39(4):422-424
CountryChina
Language:Chinese
Abstract: Objective To explore the changes of renal histology of neonatal rats with prolonged hyperoxic lung injury.Methods One-day-old rats were continuously exposed to oxygen ( 80％ ± 5％,n =60 ) or room air( 21％,n =60) after birth.HE stained renal samples were scored to evaluate the changes of histology on day 1,3,7,14,21 in the hyperoxia and control group.Results Compared with control group,hyperoxic group showed mild renal damage.Renal tubular hydropic degeneration,edema,dilation could be seen on day3,7.Renal tubular interstitial vessel dilation,congestion,and rare tubular hemorrhage,necrosis,regeneration could be seen on 14,21days.Fibrosis was not founded.There was no significant difference of histologic scores within 3 days (P ＞0.05 ),but after 7 days the difference of two groups were singnificant between the control and hyperoxia groups(P ＜0.05).Conclusions Hyperoxia exposure can lead to mild renal histology damage in neonatal rats with hyperoxic lung injury.