STIM1/Orai1 may be a new target for the prevention and treatment of ischemic cerebrovascular disease

VernacularTitle:STIM1/Orai1可能是防治缺血性脑血管病的新靶点
Author: Yuyou ZHU ; Huaiyu LI
Publication Type:Journal Article
Keywords: STIM 1 protein,humam; ORAI1 protein,human; STIM1,Orail,Vascular Smooth Muscle Cells,thrombosis,angiogenesis
From: International Journal of Cerebrovascular Diseases 2012;20(5):368-371
CountryChina
Language:Chinese
Abstract: In recent years,two important component proteins of the calcium release-activated calcium channel (CRAC) were identified fromDrosophila cells by RNA interference technique,including the calcitum sensor stromal interaction molecule 1 (STIM1) on the endoplasmic reticulum and the CRAC channel protein Orail on the cell membrane.Studies have shown that STIM 1 and Orail have regulatory effects on vascular smooth muscle cells,platelets,vascular endothelial cells and other cells.They play important roles in the aspects of vascular smooth muscle cell phenotypic modulation,hemostasis,thrombosis,and neovascularization.It shows that they both may be closely associated with ischemic cerebrovascular disease.This article reviews the advances in research on STIM1 and Orail proteins in ischemic cerebrovascular disease in order to investigate the possibility of STIM1/Orai1 as a new target in the prevention andtreatment of ischemic cerebrovascular