Association of single nucleotide polymorphisms in inflammation-related genes with amnestic mild cognitive impairment
10.3760/cma.j.issn.1674-6554.2012.05.008
- VernacularTitle:遗忘型轻度认知障碍与炎症相关基因多态性关联研究
- Author:
Liying ZHUANG
;
Zhijun ZHANG
;
Chunxian YUE
;
Hao SHU
;
Xiaoyan LIU
;
Xiaohui XU
;
Hui YU
;
Yongmei SHI
- Publication Type:Journal Article
- Keywords:
Amnestic mild cognitive impairment;
Inflammation;
Single nucleotide polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(5):410-413
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo examine whether the single nucleotide polymorphisms in inflammation-related genes are associated with the risk of amnestic mild cognitive impairment (aMCI).MethodsThe study recruited 116 aMCI patients and 93 matched healthy controls.All subjects underwent extensive assessment of cognitive function,genotyping was carried out on the platform of matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.Results ( 1 ) There was prominent discrepancy between aMCI and controls in the memory,attention and executive functions,20 minutes delayed recall of auditory verbal memory test (AVMT) (3.0(0.0 ～ 10.0 ),8.0 (0.0 ～ 12.0),t =- 8.533,P ＜ 0.05 ),recall of Rey-Osterrieth complex figure test ( R-O CFT) (11.2 ±8.3,16.1 ±8.0,t=4.216,P＜0.05),digit span test (DST) (12.0(7.0 ～ 19.0),13.0(7.0 ～20.0),Z=-2.516,P＜0.05),trail making test A (TMTA) (80.0s(35.0 ～200.0)s,72.0s(29.0 ～512.0)s,Z=-3.113,P＜0.05),trail making test B (TMTB) ((180.1 ±72.7)s,(141,7 ±52.1)s,t=-4.385,P＜0.05 ).(2) No significant differences were found in frequencies of alleles,genotypes and hapolotypes of inflammation mediator genes ( interleukin 10,interleukin 1 A,interleukin 1 B,tumor necrosis factor,interleukin 6,α1- an-tichymotrypsin gene,transforming growth factor B1 ) between aMCI and controls (P ＞ 0.05 ).ConclusionThe results indicate that polymorphisms in the inflammation-related candidate genes do not appear to be involved in the risk of developing aMCI.
