Effects of fluoxetine on special learning and memory and serum S100B level in depressed model rats
10.3760/cma.j.issn.1674-6554.2012.05.002
- VernacularTitle:氟西汀对强迫游泳大鼠空间学习记忆及血清S100B水平的影响
- Author:
Xue YU
;
Kun YANG
;
Hao LIU
;
Xiaozheng LING
;
Yanyun LI
- Publication Type:Journal Article
- Keywords:
Antidepressant;
Stress;
Learning and memory;
Astroglia-derived protein S100B
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(5):389-391
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the effects of fluoxetine on special learning and memory and serum S100B level in depressed model rats.MethodsAdult male SD rats were divided into six groups randomly according random digits table:control group ( A ),depressed model group ( B ),group of depressed model treated with single dose of fluoxetine for one day ( C ),group of depressed model treated with fluoxetine for one week (D),group of depressed model treated with fluoxetine for two weeks (E) and group of depressed model treated with fluoxetine for four weeks (F),ten rats in each group.Except control group,others were subjected to forced-swimming for four weeks,15 min a day.Fluoxetine (10 mg/kg) was given intragastric administration to group C-F before swimming everyday.Morris water maze ( MWM ) was used to measure the spatial learning and memory of rats.ELISA was used to determine the level of serum S100B.ResultsIn the hiding platform test of MWM,there was significant longer of escape latency (EL) in B group than that in A group(P ＜ 0.05 ).And the EL in all groups treated with fluoxetine became shorter with the prolonging of treatment.In the probe test,there were significant longer time in target quadrant in D,E,F than in other quadrant (F =5.162,P ＜ 0.01 ).The levels of serum S100B were lower in E,F groups ( E group ( 0.91 ± 0.23 ) ng/ml,F group ( 0.85 ± 0.21 ) ng/ml) than that in B group (( 1.26 ±0.61 )ng/ml,P＜0.05).ConclusionChronic administration of fluoxetine could improve the impairment of spatial learning and memory and reverse the increase of S100B level in serum of depressed model rats.
