Changes of cortical-limbic pathways in male recurrent unipolar major depressive disorder during attention control dysfunction
10.3760/cma.j.issn.1674-6554.2012.05.010
- VernacularTitle:男性单相复发抑郁症患者注意控制异常时脑皮层-边缘系统的动态变化
- Author:
Li HAN
;
Hao TANG
;
Qing LU
;
Haiteng JIANG
;
Zhijian YAO
- Publication Type:Journal Article
- Keywords:
Male;
Depression;
Attentional control;
Cortical-limbic pathways;
Magnetoencephalography
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(5):417-420
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study information transmission circumstances within the neural circuits related to the attentional controls of the mate depression patients.MethodsTwelve unipolar depression patients and twelve age- and education- matched healthy controls were involved in the Stroop word-color interference test to detect the variation of brain inhibitory function by Magnetoencephalography scanning.ResultsCompared with the healthy controls,the abnormally activities in depressed patients during in chronological order were separately as follow:decreased activation in the left postcentral gyrus ( t =3.10 ),the right superior frontal gyrus ( t =2.16 ),the left middle frontal gyrus (t=2.64),the left parietal lobe (t=2.89),the right middle temporal grus( t=1.92),the right superior temporal gyrus(t=2.84),the right insula(t=3.03),the right precuneus(t=2.98),the bilateral middle frontal gyros ( t =3.64,t =2.25 ),the right postcentral gyrus ( t =2.20),the right cingulate gyrus ( t =4.04 ),the bilateral precuneus ( t =2.79,t =1.87 ) ;increased activation in the left caudate body ( t =1.91 ),the left pulvinar ( t =2.56),the left middle temporal gyrus( t =1.89),the left precentral gyrus( t =2.02) (P ＜ 0.05,uncorrected).ConclusionThe abnormal activation in the brain regions related with attentional control processing is detected in the male recurrent unipolar recurrent major depression,performances of limbic system increased and.cortex declined more in the recurrent depressed.
