Comparative study of duloxetine and psychological intervention in the treatment of somatoform disorders
10.3760/cma.j.issn.1674-6554.2012.05.012
- VernacularTitle:度洛西汀联合心理干预治疗躯体形式障碍的对照研究
- Author:
Jun WANG
;
Huixia XU
;
Shouying SUN
- Publication Type:Journal Article
- Keywords:
Duloxetine;
Psychological intervention;
Somatoform disorders
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2012;21(5):424-426
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the clinical efficacy of duloxetine combined with psychological intervention in patients with somatoform disorder.Methods67 patients with somatoform disorder were randomly divided into two groups:study group (34 cases) treated with duloxetine and psychological intervention and control group (33 cases) treated with duloxetine only.And all the 67 patients in the study were assessed by symptom checklisth-90-R (SCL-90),hamilton anxiety scale(HAMA) and global assessment scale(GAS).ResultsAfter 8 weeks treatment,the results of SCL-90 showed that the scores of somatization,obsessive-compulsive,depression,anxiety and phobia factors in the study group ( 1.39 ± 0.45 ; 1.66 ± 0.52 ; 1.83 ± 0.69 ; 1.73 ± 0.66 ; 1.30 ± 0.48 )were notably lower than that in the control group ( 1.78 ± 0.61 ; 1.69 ± 0.47 ;2.39 ± 0.54 ; 2.1 1 ± 0.49 ; 1.49 ±0.78 ).And there were significant statistical differences (P＜ 0.01 ).At the end of the 2nd and 4th week the,scores of SCL-90 somatization,depression,anxiety and phobia factors were lower in the study group than the control group with statistical significance (P＜0.05).At the end of 8th week,the HAMA score in the study group( 10.20 ±3.70) was significantly decreased than the control group (13.07 ± 3.20 ),and with statistical significant (P ＜0.05 ).The response rate was 85.29％ in study group and 60.60％ in control group.And there was a statistically singnificant difference in complete remission ( χ2 =4.08,P ＜ 0.05 ) between the two groups.ConclusionThe study indicates that the combination of duloxetine and psychological intervention is more effective in treating somatoform disorder than using duloxetine only.So this combination treatment is worth generalizing and applying.
