Changes of serum GH/IGF- Ⅰ axis and related clinical significance following traumatic long bone fracture
10.3760/cma.j.issn.1001-8050.2012.05.006
- VernacularTitle:长骨骨折后血清生长激素/胰岛素样生长因子-Ⅰ轴的变化及临床意义
- Author:
Xiaolin ZHANG
;
Xiaolei SUN
;
Xinlong MA
- Publication Type:Journal Article
- Keywords:
Fractures,extremities;
Growth hormone;
Insulin-like growth factor-Ⅰ
- From:
Chinese Journal of Trauma
2012;28(5):407-411
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the changes of serum growth hormone (GH)/insulin-like growth factor- Ⅰ ( IGF- Ⅰ ) in patients with traumatic long bone fractures and the related clinical significance.MethodsTwenty-one patients with traumatic long bone fractures from the same trauma care center treated between November 2009 and April 2010 were enrolled in the study..There were 14 males and 7 females,at age range of 22-60 years (mean 45.0 years).Seventeen patients (81％) were with closed trauma and four ( 19％ ) with open trauma.Enzyme Linked Immunoadsorbent Assay (ELISA) was used to determine the levels of serum GH and IGF- Ⅰ within 14 days after fractures and the relationship between changes of GH-IGF- Ⅰ axis and injury severity score (ISS) was further analyzed.Eight patients with normal GH/IGF- Ⅰ were set as control group.ResultsThe GH level in the peripheral blood was significantly higher at day 1 after fractures ( P ＜ 0.05 ),and rapidly declined and stabilized at day 5 compared with the control group.The GH level in the patients with ISS≥ 18 points was sigmficantly higher than that in those with ISS＜18 points at day 1 after fractures (P＜0.05).The IGF- Ⅰ level in the peripheral blood in the patients with 1SS≥ 18 points was significantly higher than that in those with ISS ＜ 18 points at days 5-10 after fractures ( P ＜ 0.05 ).ConclusionThe hypothalamus GH-IGF- Ⅰ axis plays an important role in early metabolism and fracture healing during the acute phase of traumatic long bone fractures.
