Clinlcal study of hyper-fractionated three-dimensional conformal radiotherapy combined with transcatheter arterial chemoembolization for treating patients with inoperable primary livercancer
10.3760/cma.j.issn.1673-4904.2012.17.004
- VernacularTitle:大分割三维适形放疗联合经导管动脉化疗栓塞治疗不能手术原发性肝癌临床研究
- Author:
Zongyi GAO
;
Jibao ZHANG
;
Jiangtao LIU
;
Yongli LIU
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Chemoembolization,therapeutic;
Alpha-fetoproteins;
Three-dimensional conformal radiotherapy
- From:
Chinese Journal of Postgraduates of Medicine
2012;35(17):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical effect of hyper-fractionated three-dimensional conformal radiotherapy (3DCRT) combined with transcatheter arterial chemeembolization (TACE) for heating patients with inoperable primary liver cancer.Methods One hundred and two patients with inoperable advanced primary liver cancer were divided by random digits table method into control group with 49 cases treated with TACE and observation group with 53 cases treated with hyper-fractionated 3DCRT combined with TACE.The short-term efficacy,adverse reaction and survival rate of the 1st,2nd and 3rd year and serum alpha-fetoprotein (AFP) expression after treatment in two groups were observed.Results The complete remission rate,progress rate and total efficiency were 17.0％ (9/53),11.3％ (6/53),73.6％ ( 39/53 ) in observation group,2.0％( 1/49 ),28.6％ (14/49),51.0％(25/49 ) in control group.There were significant differences between two groups (P ＜ 0.05).There was no statistical significance in adverse reactions between two groups ( P ＞ 0.05 ).The survival rates of the 1 st,2nd and 3rd year in control group were 51.0％ ( 25/49 ),28.6％(14/49),14.3％(7/49),the median survival time was 15 months;while those in observation groupwere 71.7％(38/53),52.8％(28/53),39.6％(21/53) and 20 months.The survival rates of the 2nd and 3rd year in observation group were significantly higher than those in control group respectively (P ＜0.05 or ＜0.01 ).The rate of patients with no obvious serum AFP protein change between observation group [ 9.8％(4/41) ] and control group [ 31.6％(12/38) ] had statistical significance (P ＜ 0.05).Conclusion Hyper-fractionated 3DCRT combined with TACE for treating patients with inoperable primary liver cancer has good clinical efficacy,it is worthy of clinical practice.
