Relationship between anti-cyclic Citrullinated petide antibody and cardiovascular complication associated with rheumatoid arthritis
10.3760/cma.j.issn.1008-6706.2012.11.019
- VernacularTitle:血清抗环瓜氨酸多肽抗体与类风湿关节炎心血管并发症相关性的研究
- Author:
Bing XIE
;
Ni ZOU
;
Li LI
;
Liming ZHANG
- Publication Type:Journal Article
- Keywords:
Anti-cyclic citrullinated peptide antibody;
Arthritis,rheumatoid;
Cardiovascular complications
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(11):1638-1640
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim of this study was to assess the relationship between the level of anti-CCP antibody and cardiovascular(CV) risk in rheumatoid arthritis(RA) patients.Methods A total of 78 RA patients were enrolled in the study.They were divided into two groups:40 cases with CV comphtations which were secondary from RA and 38 cases with no complications.The anti-CCP antibody was diagnosed by enzyme - linked immunoabsorbent assay(ELISA) and rheumatoid factor(RF) were assessed by immunoturbidimetry method.The relationship between the levels of the two sera auto-antibodies and CV disease associated with RA was analyzed.Results The results showed that the level of anti-CCP antibody in RA-CV disease group was significantly higher than that in simple RA group(74.6％ VS 87.3％ ).Compared with the simple RA group,the level of anti-CCP antibody in the RA-CV disease group was higher,and with significant difference between the two groups( x2 =5.07,9.04,6.48,all P ＜ 0.05 ).RF positive rate was 95.8％ of the patients with RA-CV disease while it was 76.5％ in simple RA group,and the difference between the two groups was statistically significant( x2 =33.41,26.05,34.14,all P ＜ 0.05 ).The morbidi ty between the different level of RF had remarkable difference.In RA patients with CV complations,we compared antiCCP antibody and RF by Spearman analysis,whish showed no relationship between them ( r =0.301,P =0.174 ).Conclusion The results indicated that CV disease secondary from RA was more common in old patients.In RA patients the high level of anti-CCP antibody and RF maybe play an important role in the appearance of CV disease.
