Application and curative effect of Aiyishu injection in neoadjuvant chemotherapy of breast cancer
10.3760/cma.j.issn.1008-6706.2012.09.005
- VernacularTitle:斑蝥酸钠维生素B6在乳腺癌辅助化疗中的应用
- Author:
Xiangshi LU
;
Linggen LI
;
Zhihua WANG
;
Hongbin WANG
- Publication Type:Journal Article
- Keywords:
Aiyishu injection;
Breast neoplasms;
Neoadjuvant therapy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(9):1291-1292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the synergetic effect of Aiyishu injection in combination with neoadjuvant chemotherapy in the treatment patients with breast cancer.Methods Seventy patients with breast carcinoma at stage Ⅰ - Ⅲ were randomly divided into treatment group( Aiyishu associated CAF regimen)( n =36) and control group ( CAF regimen) ( n =34).The activities of T cells and NK cells,response rate,change of clinical symptoms,adverse effects and living quality were evaluated in patients of two groups.Results The levels of CD3,CD4,CD8 and the ratio of CD4/CD8 and the activity of NK cells in treatment group were higher than those in control group( P ＜0.05) ;the response rate was 41.67％ and 36.67％ in group 1 and 2 respectively,but had no significant difference;the incidence rates of leucopenia and gastrointestinal disturbance were 33.33％ and 38.89％ respectively in patients of treatment group,whereas the rates were 67.65％ and 67.65 ％,in control group ( P ＜ 0.05).In treatment group,KPS increased in 36.11％ (13/36) patients,and it was higher than that in control group (11.76％,4/34 )( P ＜0.05).Conclusion Aiyishu injection can increase the ability of immunity of body and reduce the toxic and adverse reaction,and improve the living quality in patients with breast cancer when it is used in pre-operative chemotherapy of breast cancer.
