Clinical significance of the determination of bone biochemical metabolic markers in osteoporosis

VernacularTitle:骨质疏松症患者骨代谢指标检测的临床价值
Author: Haiying JIA ; Huixia MA ; Jianglin REN ; Yongfang TIAN
Publication Type:Journal Article
Keywords: Bones metabolism; Osteoporosis
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(9):1312-1313
CountryChina
Language:Chinese
Abstract: Objcetive To evaluate the clinical significance of bone biochemical metabolic markers in osteoporosis( OP),and investigate the clinical application value of the determination.Methods BMD at various skeletal sites was measured by XR-36 dual energy X-ray absorptiometry for 65 patients.Enzyme linked immunosorbent assay (ELISA) were used to determine bone biochemical metabolic markers in sera of 65 patients with osteoporosis and 62healthy controls.Results The levels of serum TRACP5b and 25-OH-VD3/25-OH-VD2 in OP group were higher than that in control group( P ＜0.05),meanwhile the level of BGP,BAP and Ca were varying degrees higher than that in control group,but the level of P was lower than that in control group.Conclusion TRACP5b,BGP,BAP,VD3/2 and other bone metabolic markers can be used as indicators of early detection of osteoporosis,in order to provide valuable data for early treatment of osteoporosis.