A controlled clinical trial of radiotherapy combined with docetaxol and cisplatin in the treatment of locally advanced non-small cell lung cancer
10.3760/cma.j.issn.1008-6706.2012.09.016
- VernacularTitle:多西他赛与顺铂联合放疗治疗晚期肺癌疗效比较
- Author:
Hecheng HUANG
;
Zhiyuan XU
;
Lianxing LIN
;
Hesan LUO
;
Shengxi WU
- Publication Type:Journal Article
- Keywords:
Lung Neoplasms;
Antincoplasm combined chemotherapy protocols;
Radiotherapy,Conformal
- From:
Chinese Journal of Primary Medicine and Pharmacy
2012;19(9):1314-1316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effectiveness and the major toxic effect of radiotherapy combined with docetaxol and cisplatin respectively in the treatment of locally advanced non-small cell lung cancer (NSCLC).Methods 98 patients with locally advanced NSCLC were randomly divided into two groups.All of the patients were treated with 3D-CRT.One group was treated combined with docetaxel,20mg/m2,every week,totally 6 times.The other group was treated combined with cisplatin,30mg/m2,every week,totally 6 times.The total dose was 60 ～66Gy,2Gy/F,5 times each week for 5 ～7 weeks.The clinical effect and the major toxic effect between two groups were compared.Results The median survival time in group that treated with docetaxol was 17.2 months,median progression-free survival time was 13.5 months,and the 1,2 and 3-year survival rates of the patients were 78.6％,35.7％ and 19.5％ respectively.The median survival time in group that treated with cisplatin was 16 months,median progression-free survival time was 16.5 months,and the 1,2 and 3-year survival rates of the patients were 74％,34％ and 20％ respectively.The differences between two group were not stetisticelly significant( P ＞0.05 ).However,the side effect of the stomach and intestine and late radiation complication in group treated with docetaxol were slighter than those in group treated with cisplatin.Conclusion The clinical effect of radiotherapy combined with docetaxol in the treatment of locally advanced NSCLC was equal to radiotherapy combined with cisplatin.But radiotherapy combined with docetaxol has a slighter and acceptable toxic effect,which was worth the clinical application.
