The expression and significance of P57KIP2 in hydatidifotrm mole

VernacularTitle:P57KIP2蛋白在葡萄胎组织中的表达及意义
Author: Yuan YANG
Publication Type:Journal Article
Keywords: Immunologic tests; Hydatidiform mole
From: Chinese Journal of Primary Medicine and Pharmacy 2012;19(9):1331-1332
CountryChina
Language:Chinese
Abstract: Objective To study the expression and significance of P57KIP2 in complete mole(CM ) and partial mole(PM).Methods The expression of P57KIP2 in histology unequivocal 45 cases of CM and 30 cases of PM was detected by immunohistochemistry method.Results In the PMs,expression of P57kip2 was strongly and continuously(30/34),in the CMs,it was absent or weak expressed (5/45).The difference of P57K1P2 expression between PMs and CMs was statistically significant( P ＜ 0.05 ).Conclusion P57KIP2 immunostaining is a sensitive sign of partial moleand in differential diagnosis of PM from CM and it is deserving of clinical application.