Roles of SUMOylation and de-SUMOylation in carcinogenesis
10.3760/cma.j.issn.1673-422X.2012.06.002
- VernacularTitle:SUMO化和去SUMO化在肿瘤发生中的作用
- Author:
Dan HU
;
Fuxiang CHEN
- Publication Type:Journal Article
- Keywords:
Sumoylation;
Amino acid motifs;
Neoplasms
- From:
Journal of International Oncology
2012;39(6):406-408
- CountryChina
- Language:Chinese
-
Abstract:
SUMO (small ubiquitin-related modifier) is involved in the post-translational modifications of proteins,and this process is referred to as SUMOylation.SUMOylation plays an important role in the regulation of cellular activities such as strengthening the stability of the protein,nucleocytoplasmic transport,DNA repair,DNA replication,mitotic and meiotic chromosome behavior,et al.SUMOylation is a dynamic process and can be reversed by SUMO-specific proteases (SENP).Once the balance between SUMOylation and de-SUMOylation is broken,there will be an aberrant expression of SUMO or SENPs in cells to happen,which may lead to the tumor occturtrence.
