Roles of the liver regeneration phosphatase-3 and its inhibitors in tumor
10.3760/cma.j.issn.1673-422X.2012.06.005
- VernacularTitle:肝再生磷酸酶-3及其抑制剂在肿瘤中的作用
- Author:
Wenjuan WANG
;
Taiping HE
- Publication Type:Journal Article
- Keywords:
Protein tyrosine phosphatases;
Neoplasm;
Signal transduction;
Tyrphostins
- From:
Journal of International Oncology
2012;39(6):415-417
- CountryChina
- Language:Chinese
-
Abstract:
Phosphatase of regenerating liver-3 (PRL-3) is a novel small molecule protein-tyrosine-phosphatase,which plays an important role in the oncogenesis and deveopment of tumors.Studies show that PRL-3 regulates neoplasm progress through participating in multiple signal pathways.Its high expression can significantly promote neoplasm metastasis in cancer tissue.However,there is no expression of PRL-3 in most normal tissue.PRL-3 is expected to be a potential tumor maker of diagnosis and a new target for the therapy of cancer.
