Tumor microenvironment related type 17 T helper cells
10.3760/cma.j.issn.1673-422X.2012.06.006
- VernacularTitle:肿瘤微环境相关17型辅助性T细胞
- Author:
Hui WANG
;
Jie LI
;
Baojin HUA
;
Guizhi SUN
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Inflammation;
Th17 cell
- From:
Journal of International Oncology
2012;39(6):418-421
- CountryChina
- Language:Chinese
-
Abstract:
Type 17 T helper cells (Th17) are novel subsets of CD4+ effector T cells discovered recently which are different from the traditional type 1 and type 2.They are mainly differentiated from initial T cell precursor.Tumor microenvironmental cytokines can recruit CD4 + Th17 cells from the peripheral blood into tumor sites.And the differentiation of Th17 cells is also affected by tumor microenvironmental factors.Tumorinfiltrating Th17 cells play a dual role for tumor growth in both pro- and anti-tumourigenic processes.A further understanding of the activities of Th17 cells will provide a new breakthrough point for the researches of cancer immunotherapy.