Antitumor effect of inhibitor of growth 4
10.3760/cma.j.issn.1673-422X.2012.06.007
- VernacularTitle:生长抑制因子-4抗肿瘤作用
- Author:
Dahang ZHAO
;
Baoxin WANG
;
Wenbo WANG
- Publication Type:Journal Article
- Keywords:
Cytokines;
Neoplasms;
Genes,tumor suppressor
- From:
Journal of International Oncology
2012;39(6):422-424
- CountryChina
- Language:Chinese
-
Abstract:
Inhibitor of growth 4 (ING4) is an important member of anti-oncogene family.The expression of ING4 is significantly lower in many malignancies.ING4 involves in multiple processes,such as tumorigenesis,regulation of cell cycle,cell apoptosis,DNA repair and angiogenesis,which have a significant impact on the progression and prognosis of tumor.ING4 may serve as a promising prognostic maker as well as a potential therapeutic target for cancer.
