Effect of cyclooxygenase-2 inhibitor in anti-leukemia
10.3760/cma.j.issn.1673-422X.2012.06.019
- VernacularTitle:环氧合酶-2抑制剂抗白血病作用研究
- Author:
Xia XIE
;
Hongling HAO
- Publication Type:Journal Article
- Keywords:
Leukemia;
Cell cycle;
Apoptosis
- From:
Journal of International Oncology
2012;39(6):462-464
- CountryChina
- Language:Chinese
-
Abstract:
Cyclooxygenase-2 (COX-2) plays an important role in the development of leukemia.COX-2 inhibitor plays a certain anti-leukemia role in the process.Many studies show that COX-2 inhibitor plays antileukemia role by inhibiting the proliferation of leukemia cell,promoting apoptosis,affecting cell cycle,inhibiting cell metastasis and reversing cell drug resistance and so on.Therefore,the researches about the anti-leukemia mechanisms of COX-2 inhibitor will provide a new target in clinical prevention and treatment of leukemia.
