Prognostic value of fluid responsiveness in acute respiratory stress syndrome
10.3760/cma.j.issn.1671-0282.2012.06.013
- VernacularTitle:液体反应性对急性呼吸窘迫综合征的预后价值
- Author:
Jun LU
;
Yueping DING
;
Fei WANG
;
Zimiao ZHAO
;
Xiaolin YE
;
Dannv MA
;
Xiling SONG
- Publication Type:Journal Article
- Keywords:
Acute respiratory stress syndrome;
Mechanical ventilation;
Stroke volume;
Prognosis;
Mortality;
Hemodynamics;
Fluid responsiveness;
Critical care
- From:
Chinese Journal of Emergency Medicine
2012;21(6):612-616
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the prognostic value of fluid responsiveness in patients with acute respiratory stress syndrome (ARDS).Methods Fifty-nine mechanically ventilated patients with ARDS were enrolled.Their stroke volume variations (SVV) were detected by pulse contour continuous cardiac output (PiCCO) analysis device,and then the patients were subsequently divided into fluid responsive group (SVV≥15％) and fluid non-responsive group (SVV ＜ 15％ ).The differences in 28-day survival,length of ICU stay and duration of mechanical ventilation between the 2 groups were compared.Thereafter,the 28-day survival of patients was analyzed by Kaplain-Meier survival model and the relationship between SVV and mortality within 28 days was analyzed by logistic regression model.Results In comparison with fluid non-responsive group,the 28-day survival of fluid responsive group was significantly increased (85.3％ vs.56.0％,P =0.012),the length of ICU stay was significantly shortened [( 13.1 ±5.2 ) d vs. (21.6±9.0) d,P=0.008],and the duration of mechanical ventilation was significantly shortened as well [( 11.4 ± 5.3 ) d vs.( 18.3 ± 4.9) d,P =0.022] ; Logistic analysis revealed that SVV ＜ 15％ increased the risk of 28-day mortality ( OR =4.82 ; 95％ CI:2.67 ～ 11.71,P =0.009 ).ConclusionsSVV-based fluid responsiveness can be served as a prognostic predictor for ventilated patients with ARDS.
