Negative regulation of transforming growth factor-β superfamily co-receptor Ⅲ in tumorigenesis
10.3760/cma.j.issn.1673-422X.2012.06.004
- VernacularTitle:转化生长因子-β受体Ⅲ负性调控肿瘤发生的研究
- Author:
Shusheng ZHANG
;
Biao ZHANG
;
Jinhuan WANG
- Publication Type:Journal Article
- Keywords:
Receptors,transforming growth factor beta;
Signal transduction;
Neoplastic processes
- From:
Journal of International Oncology
2012;39(6):411-414
- CountryChina
- Language:Chinese
-
Abstract:
The expression of transforming growth factor(TGF)-β supeffamily co-receptor (Tβ3R) Ⅲ is often lost in many kinds of cancers.Tβ3RⅢ plays a role of negative regulation in tumorigenesis.T3RⅢ could regulate the cellular invasion,migration,proliferation and apoptosis by multiple mechanisms,such as mediating the TGF-β signaling pathway,impacting the mitogen-activated protein kinase(MAPK),nuclear factor-kappa B (NF-κB) and Cdc42 and producing soluble TβR(sTβR) Ⅲ.Defining the mechanisms of absence and physiological functions of TβR Ⅲ in cancers has great significant for the diagnosis,treatment and prognosis of cancer.
