Research on aberrant expression of HOX in gastrointestinal neoplasms and its mechanism
10.3760/cma.j.issn.1673-4203.2012.06.012
- VernacularTitle:同源框基因在消化道肿瘤中的异常表达及相关机制研究
- Author:
Yang HAN
;
Chongzhi ZHOU
- Publication Type:Journal Article
- Keywords:
HOX genes;
Esophageal neoplasms;
Gastric neoplasms;
Colorectal neoplasms
- From:
International Journal of Surgery
2012;39(6):396-399
- CountryChina
- Language:Chinese
-
Abstract:
Homebox genes are known to determine cell proliferation and differentiation and subsequently regulate the occurrence,development and prognosis of many tyhpes of malignant tumors in human.Some recent studies have shown that homebox genes are abnormally expressed in the esophageal,gastric,coloreetal and other gastrointestinal tumors.In this review,we consider that homebox genes may regulate the occurrence,development of gastrointestinal tumors by interacting with transcription factors in vivo and abnormal epigenetic modifications.Therefore,homebox genes are closely related to gastrointestinal tumors.
