Expressions of heparinase, matrix metalloproteinase 2 and tissue inhibitor of metalloproteinase 2 in malignant melanoma
10.3760/cma.j.issn.0412-4030.2012.06.014
- VernacularTitle:乙酰肝素酶、基质金属蛋白酶2和金属蛋白酶组织抑制剂2在恶性黑素瘤的表达
- Author:
Jianli CHEN
;
Jiangan ZHANG
;
Jianbin YU
;
Beibei SU
;
Jing MENG
- Publication Type:Journal Article
- Keywords:
Melanoma;
Heparinyase;
Matrix metalloproteinase 2;
Tissue inhibitor of metalloproteinase 2
- From:
Chinese Journal of Dermatology
2012;45(6):422-425
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expressions ofheparinase,matrix metalloproteinase 2 (MMP2) and tissue inhibitor of metalloproteinase 2(TIMP2) in malignant melanoma lesions and their significance.MethodsSkin specimens were obtained from the lesions of 30 patients with malignant melanoma,30 patients with melanocytic nevus and the normal skin of 15 healthy controls.Immunohistochemical SP method was used to detect the protein expression of heparinase,MMP2 and TIMP2.ResultsThe malignant melanoma tissue specimens significantly differed from the melanocytic nevus and control tissue specimens in the expression rate of heparinase (63.33％ vs.6.67％ and 0.00,x2 =21.172,27.805,both P ＜ 0.01 ),MMP2 (70.00％ vs.13.33％ and 0.00,x2 =19.817,19.866,both P＜ 0.01) and TIMP2(60.00％ vs.6.67％ and 0.00,x2 =19.200,15.000,both P ＜ 0.01 ).ConclusionThe expression of heparinase,MMP2 and TIMP2 is significantly higher in malignant melanoma lesions than in melanocytic nevus lesions and normal skin tissue.
