Angiopoietin-2 and tumor angiogenesis
10.3760/cma.j.issn.1673-422X.2012.05.009
- VernacularTitle:血管生成素-2与肿瘤血管生成的研究进展
- Author:
Anhong ZHENG
;
Weidong ZHANG
- Publication Type:Journal Article
- Keywords:
Angiopoietins;
Neoplasms;
Neovascularization,pathologic
- From:
Journal of International Oncology
2012;39(5):352-355
- CountryChina
- Language:Chinese
-
Abstract:
Tumor angiogenesis is an important way of rapid proliferation and metastasis for malignancies,and a variety of cellular and molecular factors involved in the process.Angiopoietin-2(Ang-2) is one of the important vascular endothelial growth factor,which influences tumor angiogenesis mainly through releasing vascular structures and damaging the vessel stability.Recent researches reveal that Ang-2 modulates tumor angiogenesis interacting with other vascular growth factors.With the new research progress,Ang-2 will not only be an important target for antiangiogenic therapy,but also further improve clinical efficacy of antitumor therapy combined with other signal pathways as common targets.
