Basal-like breast cancer
10.3760/cma.j.issn.1673-422X.2012.05.016
- VernacularTitle:基底细胞样乳腺癌
- Author:
Shenglan LI
;
Qingyuan ZHANG
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Molecular pathology;
Therapy
- From:
Journal of International Oncology
2012;39(5):377-380
- CountryChina
- Language:Chinese
-
Abstract:
Basal-like breast cancer (BLBC) is a basal cell phenotype and associated with different levels of expression in basal cell keratin and (or) myoepithelial markers in breast cancer,which has a unique genetic phenotype and morphological characteristics.BLBC is prevalent in young woman,and it is easy to relapse and metastasis. Additionally,most BLBC has expression loss of estrogen receptor and progesterone receptor and human epidermal growth factor receptor 2,which limits the targeted therapeutic options for these predominantly triple-negative breast cancers.
