Epidemiology and distribution of hepatitis C virus genotype among HIV positive former blood donors and transfusion recipients in Hubei province

VernacularTitle:湖北省部分地区经血途径感染艾滋病人群中丙型肝炎病毒基因型分布
Author: Liping DENG ; Xien GUI ; Shicheng GAO ; Yong XIONG ; Rongrong YANG ; Mingqi LUO
Publication Type:Journal Article
Keywords: Human immunodeficiency virus(HIV); Hepatitis C virus(HCV); Genotype
From: Chinese Journal of General Practitioners 2012;11(6):441-443
CountryChina
Language:Chinese
Abstract: ObjectiveTo explore the epidemiologic features and distribution pattems of hepatitis C virus (HCV) genotype infection among HIV positive former blood donors (FBDs) and transfusion recipients in Hubei province.Methods597 serum samples from HIV-positive patients in Hubei were collected and examined for anti-HCV by enzyme-linked immunosorbent assay ( ELISA ).Reverse transcription nested polymerase chain reaction (RT-nested PCR) amplification and DNA sequencing were used to evaluate the HCV core regions.ResultsThe prevalence rates of HCV in HIV positive FBDs and transfusion recipients were 76.5％ (205/268) and 57.4％ (189/329) respectively.HCV genotypes 1b (92.8％,90/97) and 2a (7.2％,7/97 ) were detected.ConclusionsBlood donation and blood transfusion are the major modes of HIV-HCV co-infection in Hubei province.The prevalence of HCV in HIV positive transfusion recipients is lower than that in HIV positive FBDs.HCV genotypes 1b and 2a are the predominant strains among HIV-positive FBDs and transfusion recipients.