Regulation of cyclin E and cancers
10.3760/cma.j.issn.1673-422X.2012.05.005
- VernacularTitle:细胞周期蛋白E的调控与恶性肿瘤
- Author:
Cuiping GUO
;
Guojun ZHANG
- Publication Type:Journal Article
- Keywords:
Cyclin E;
Cell cycle regulation;
Cyclins;
Neoplasms
- From:
Journal of International Oncology
2012;39(5):337-340
- CountryChina
- Language:Chinese
-
Abstract:
Cyclin E is expressed starting from the middle G1 phase of the cell cycle,and is accumulated in the G1/S boundry.Cyclin E binds to and activates the cyclin-dependent kinase CDK2.Cyclin E-CDK2 complex initiates a cascade of events that leads to DNA replication by phosphorylating its substrates,such as Rb,CDC6,NPAT and P107,etc.Additionally,cyclin E plays an important role in the regulation of genomic stability,spindle-organizing structure and centrosome cycle.Cyclin E expression is trans-activated by members of the transcription factor E2F family and degrades via the ubiquitin-proteasome pathway.At the same time,it is also negatively regulated by the CIP/KIP proteins.Cyclin E highly expressed in the initiation and progression of different human cancers,such as breast cancers,lung cancers,leukemia,lymphomas and others.
