Astrocyte elevated gene 1 in malignant tumor

VernacularTitle:星形胶质细胞上调基因-1在恶性肿瘤中的研究
Author: Cheng DU ; Xiaodong XIE
Publication Type:Journal Article
Keywords: Neoplasms; Oncogenes
From: Journal of International Oncology 2012;39(5):341-344
CountryChina
Language:Chinese
Abstract: Recent studies suggest that astrocyte elevated gene 1 ( AEG-1 ) is almost highly expressed in all types of malignant solid tumors and correlates with poor prognosis,which becomes a prognostic marker for many kinds of tumors.As a strongly basic protein,AEG-1 possesses a transmembrane domain and multiplenuclear localization signals.It is present in the cell membrane,cytoplasm and nucleus.As an oncogene,AEG-1 palys an important role in a virety of malignant biological behaviors of cancer,which range from cell proliferation,apoptosis,migration,adhesion,invasion to tumor angiogenesis and chemotherapy resistance.Its critical role in tumor genesis and progression has made it a potential therapeutic target.