The effects of Tong Xin-Luo on human umbilical vein endothelial cells impaired by lysophosphatidylcholine

VernacularTitle:通心络对溶血磷脂酰胆碱所致人脐静脉内皮细胞损伤的影响
Author: Min YANG ; Jingfang LIU ; Ming SUN ; Huifang SHEN ; Hongyan ZHOU
Publication Type:Journal Article
Keywords: Cardiovascular agents/therapeutic use; Capsules △; Lysophosphatidylcholines/adverse effects; Vascular diseases/chemically induced/therapy; Umbilical veins/pathology; Endothelium,vascular/pathology
From: Journal of Chinese Physician 2012;14(5):607-609
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of Tong Xin-Luo on cultured human umbilical vein endothelial cells (HUVECs) impaired by Lysophosphatidylcholine.Methods The herbage-contained serum of TXL was prepared,HUVECs were cultured in vitro.The study was designated to 4 group:normal control,LPC group,TXL group,and TXL + LPC intervened group.The cell function was determined by cell morphology and MTT colorimetric assay.Results Compaired with normal control group (0.380 ±0.023 ),LPC ( 0.320 ± 0.024 ) could significantly decrease the cells activity,promote cells death ( P ＜0.05 ).After TXL intervened(0.424 ±0.034),cells activity was significantly increased,cells death was d significantly decreased( P ＜0.05 ).Conclusions Tong Xin-Luo could protect human umbilical vein endothelial cells function by against the LPC-induced damage.