Thyroid autoantibodies: adverse effects on pregnancy outcomes and child development and its intervention
10.3760/cma.j.issn.1000-6699.2012.05.021
- VernacularTitle:甲状腺自身抗体对妊娠结局和后代的影响及干预
- Author:
Haixia LIU
;
Zhongyan SHAN
- Publication Type:Journal Article
- Keywords:
Thyroid autoantibodies;
Autoimmunity;
Pregnancy outcomes;
Intervention
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(5):441-444
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid autoantibodies (TAA) in euthyroid women were associated with several adverse pregnancy outcomes,such as miscarriage,preterm birth.Maternal TAA frequently results in transient mild elevation of serum TSH above the normal reference value in women during pregnancy and in infants born in the first month of life,and may affect neuropsychological development of their offspring.The cause is still unclear.Medical interventions on TAA involve levothyroxine or selenium supplementation. The article reviews the effects of maternal thyroid autoantibodies on pregnancy outcomes,as well as on neonatal thyroid status,and neuropsychological development of the fetus and neonate,and summarizes therapeutic strategies used to intervene maternal thyroid autoimmunity.
