Retrospective analysis on switch between ciclosporin A and tacrolimus in triple immunosuppressive protocol after renal transplantation
10.3760/cma.j.issn.0254-1795.2012.06.003
- VernacularTitle:肾移植后三联免疫抑制方案内环孢素A与他克莫司相互转换的回顾性分析
- Author:
Yang LI
;
Wujun XUE
;
Puxun TIAN
;
Xiaoming DING
;
Xiaoming PAN
;
Hang YAN
;
Xinshun FENG
;
Jun HOU
;
Heli XIANG
;
Xiaohui TIAN
;
Chenguang DING
;
Jin ZHENG
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Cyclosporine;
Tacrolimus;
Conversion treatment
- From:
Chinese Journal of Organ Transplantation
2012;33(6):327-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the clinical significance of switch between ciclosporin A (CsA) and tacrolimus (TAC) in the triple immunosuppressive protocol including calcineurin inhibitors (CNI),mycophenolate mofetil (MMF),and prednisone (Pred) after renal transplantation.Methods The data of 148 patients with CNI switch were collected from Jan.2000 to Dec.2010,including 51patients with Tac switching to CsA (group A) and 97 patients with CsA switching to Tac (group B).The clinical indexes were analyzed by paired t-test.Results In group A,the serum creatinine,urea and blood glucose were significantly reduced,and hemoglobin,bilirubin,cholesterol significantly increased as compared with those before switch (P＜0.05).In group B,the serum creatinine and urea began were significantly reduced from 4th and 2nd week respectively after switch (P＜0.05).Platelet counts began significantly dropping from 20th week after switch (P＜0.05).Albumin,globulin and bilirubin were significantly increased from 20th,12th and 36th week respectively after switch (P＜0.05).Blood glucose and cholesterol were significantly decreased from 12th and 3rd week respectively after switch (P＜0.05).The trough concentrations of CNI and MMF AUC kept stable before and after switch.Conclusion The renal function of all patients was improved to varying degrees by CNI switch between CsA and Tac no matter what reason.The switch of immunosuppressive agents has benefits to alleviate adverse reactions.
