Mechanisms of oxaliplatin neurotoxicity and its predictions
10.3760/cma.j.issn.1673-422X.2012.05.013
- VernacularTitle:奥沙利铂神经毒性机制及预测
- Author:
Yang WANG
;
Jisheng LI
;
Xiuwen WANG
- Publication Type:Journal Article
- Keywords:
Oxaliplatin;
Neurotoxins;
Tumor markers,biological
- From:
Journal of International Oncology
2012;39(5):366-369
- CountryChina
- Language:Chinese
-
Abstract:
As the main drug in colorectal cancer chemotherapy,oxaliplatin is gradually infiltrated into other malignancies therapy.But oxaliplatin-induced peripheral neuropathy limits its clinical application.The mechanisms of oxaliplatin neurotoxicity are not yet clear.Recent researches show that the acute neurotoxicity of oxaliplatin is mediated through changes in Na + transient conductances.And the function of the mitogen-activated protein kinases in chronic neuropathy has already been demonstrated in vitro.Furthermore,numerous indicators can be used to predict oxaliplatin-induced peripheral neuropathy,which bring the hope for improving the continuity of chemotherapy and realizing personalized medicine therapy.
