The influence of glucose-lowering rate on CKMB and muscle hemoglobin in type 2 diabetes mellitus with coronary heart disease
10.3760/cma.j.issn.1000-6699.2012.05.012
- VernacularTitle:降糖速度对2型糖尿病合并冠心病患者肌酸激酶同工酶和肌红蛋白的影响
- Author:
Zhaohui ZHENG
;
Weihua WU
;
Zhenjie SUN
;
Mingli WANG
;
Jiajing MIAO
;
Qian LI
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Coronary heart disease;
Glucose-lowering rate;
MB isoenzyme of creatine kinase;
Muscle hemoglobin
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(5):407-411
- CountryChina
- Language:Chinese
-
Abstract:
One hundred and fifty-one type 2 diabetic patients with coronary heart disease ( T2 DMC) and 142 cases of type 2 diabetes mellitus were included for analyzing the influence of different glucose-lowering rates on MB isoenzyme of creatine kinase (CKMB) and muscle hemoglobin level changes to search for the rational glucose-lowering rate.The level of CKMB in type 2 deabetes mellitus group was significantly lower( P＜0.05 ) at follow-up than that before and after intensive therapy.In type 2 diabetes mellitus group,when the fasting or postprandial glucose-lowering rate was not greater than 6 mmol· L-1 · d-1,the level of CKMB and muscle hemoglobin were significantly lower at follow-up than that before intensive therapy ( P＜0.05 ).When the fasting glucose-lowering rate is greater than 6 mmol· L-1 · d-1,the level of CKMB is significantly higher after intensive therapy than that before glucose-lowering ( P＜0.05 ).In T2DMC group,when the fasting or postprandial glucose-lowering rate was not greater than 4 mmol· L-1 · d-1,the level of CKMB and muscle hemoglobin was significantly lower at follow-up than that before intensive therapy(P＜0.05 or P＜0.01 ),buthigher at follow-up when the fasting glucose-lowering rate was greater than 4 mmol· L-1 · d-1(P＜0.05).
