Autophagy and cancer
10.3760/cma.j.issn.1673-422X.2012.05.001
- VernacularTitle:自噬与肿瘤
- Author:
Jun WANG
;
Xiaoping ZOU
- Publication Type:Journal Article
- Keywords:
Autophagy;
Cell death;
Neoplasms
- From:
Journal of International Oncology
2012;39(5):323-326
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a dynamic process which subcellular membranes undergo morphological changes that lead to the degradation of cellular cytoplasmic organelles and macromolecules.It is regulated by themammalian target of rapamycin ( mTOR ) -dependent or -independent signaling pathways.It has been demonstrated that autophagy is induced or inhibited in various tumor cells,and it is closely related with cell survival and drug resistance.Because of the complex relationships with cell death,the roles of autophagy in cancer developnent,treatment,and drug-resistance are not the same,and thus controlling autophagy properly may become one of new means of cancer therapy.
