Effects of simvastatin on the expression of NADPH oxidase subunits mRNA in high glucose-induced injury of cardiomyocytes in neonatal rat
10.3760/cma.j.issn.1000-6699.2012.05.015
- VernacularTitle:辛伐他汀对高糖损伤乳鼠心肌细胞NADPH氧化酶亚基基因表达的影响
- Author:
Xiqing WEI
;
Hongyong TAN
;
Jinguo ZHANG
;
Hongsheng ZHANG
;
Yu CHEN
;
Lingai HU
;
Zhihua LIU
- Publication Type:Journal Article
- Keywords:
Simvastatin;
High glucose;
Cardiomyocytes;
NADPH oxidase subunits;
Reactive oxygen species
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(5):419-422
- CountryChina
- Language:Chinese
-
Abstract:
Ventricular myocytes from hearts of the neonatal SD rats were treated with 10-7,10-6,and 10-5 mol/L simvastatin for 72 hours under high glucose condition. Compared with control group,the viability of cadiomyocyte was significantly lower in high glucose group (P＜0.01 ).The activity of lactate dehydrogenase,the relative expressions of NADPH oxidase subunits p22phox,p47phox mRNA,and reactive oxygen species level in the high glucose group were higher than those of control group ( all P＜0.05).lndexes mentioned above were significantly improved by simvastatin treatment in a dose-dependent manner.These results suggest that simvastatin ameliorates high glucose-induced injury of cardiomyocytes via increasing the expression of NADPH oxidase mRNA.
