Effect of resveratrol on the expressions of FoxO1 in kidneys of diabetic rats

VernacularTitle:白藜芦醇对糖尿病大鼠肾脏叉头转录因子O1表达的影响
Author: Lina WU ; Guijun QIN ; Na ZHANG ; Yinghui ZHANG ; Xiaokun MA
Publication Type:Journal Article
Keywords: Resveratrol; Forkhead transcription factor O1; Oxidative stress
From: Chinese Journal of Endocrinology and Metabolism 2012;28(5):423-425
CountryChina
Language:Chinese
Abstract: Streptozotocin-induced diabetic rats were treated with resveratrol for 12 weeks.Compared with group of diabetic rats without treatment,the levels of urine albumin,serum creatinine,and blood urea nitrogen were significantly decreased and pathological changes in kidney were improved in treatment group ( P＜0.05 ).The mRNA expressions of FoxO1 and catalase were higher and FoxO1 phosphorylation level in diabetic rats treated with resveratrol was lower than that in diabetic rats without treatment (P＜0.05),suggesting that resveratrol may protect the kidneys of diabetic rats via regulating expression of FoxO1.