Expression and significance of MICA, NF-κB and P53 in carcinoma of the urinary bladder
10.3760/cma.j.issn.1008-1372.2012.04.004
- VernacularTitle:膀胱癌组织中MICA、NF-κB和p53的表达和意义
- Author:
Wangdong DENG
;
Shanming LU
;
Fengtao YANG
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms/pathology/metabolism;
Histocompatibility antigens class I/metabolism;
NF-kappa B/metabolism;
Tumor suppressor protein p53/metabolism
- From:
Journal of Chinese Physician
2012;14(4):445-448
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the mechanism of the expression of MHC class Ⅰ chain-related A (MICA) in carcinoma of the urinary bladder,the relationship between MICA,nuclear factor-κB ( NF-κB) and p53 expression in bladder cancer was studied.MethodsThe expression of MICA,NF-κB and p53 in a total of 75 cases of urothelial carcinoma tissues and 15 normal mucous membrane tissues of the bladder was evaluated by immunohistochemistry.ResultsThe expression rates of MICA,NF-κB and p53 protein in urothelial carcinoma were 4.08％,85.3％ and 49.3％,respectively.Up-regulation of their expression was found in urothelial carcinoma compared with normal mucous membrane tissues ( P ＜ 0.05 ).MICA expression was positively correlated with NF-κB expression( r =0.256,P =0.027),but negatively correlated with p53 expression( r =- 0.23,P =0.047 ).ConclusionsUp-regulation of MICA expression was detected in bladder cancer.MICA protein may be a new tumor-associated antigen of bladder cancer.MICA expression may be regulated by NF-κB pathway,while p53 pathway may not play a part in MICA up-expression during the urothelial malignant transformation.
