Effect of PPARγ and glucocorticoid receptor on hepatic glucose metabolism
10.3760/cma.j.issn.1000-6699.2012.05.018
- VernacularTitle:PPARγ和糖皮质激素受体对肝细胞糖代谢的影响
- Author:
Kun HAN
;
Danping WANG
- Publication Type:Journal Article
- Keywords:
Peroxisome proliferator-activated receptor γ;
Glucocorticoid receptor;
Cross talk;
Glucose metabolism
- From:
Chinese Journal of Endocrinology and Metabolism
2012;28(5):430-432
- CountryChina
- Language:Chinese
-
Abstract:
HepG2 cells were incubated with dexamethasone,glucocorticoid receptor (GR) antagonist RU486,and pioglitazone for 24 or 48 h.Glucose concentration in culture medium was detected.The results showed that 10 μmol/L RU486 blocked the surge of glucose concentration by 48 h of dexamethasone treatment and the glucose concentration in RU486 + pioglitazone group was higher than pioglitazone group( P＜0.05 ),suggesting that the cross talk between PPARγ and GR may exist in hepatic glucose metabolism.
