Approach to the patients with medullary thyroid cancer

VernacularTitle:甲状腺髓样癌的临诊应对
Author: Xiaohua JIANG ; Jie CAI ; Lei YE ; Shu WANG ; Yongju ZHAO ; Weiqing WANG ; Guang NING
Publication Type:Journal Article
Keywords: Medullary thyroid cancer; Calcitonin; RET gene; Multiple endocrine neoplasia
From: Chinese Journal of Endocrinology and Metabolism 2012;28(5):433-438
CountryChina
Language:Chinese
Abstract: Medullary thyroid cancer (MTC) is characterized hy the secretion of calcitonin that is derived from parafollicular cells.20％-25％ of MTC are hereditary.Compared with other types of thyroid cancer,MTC is prone to recurrence,metastasis,and younger onset age.RET gene germline mutation accounts for the hereditary MTC,and somatic mutation is responsible for part of sporadic cases.A good correlation between phenotype and genotype is reported.We present in this article a case of medullary thyroid cancer patient with genetic diagnosis and treatment as well as postoperative follow-up together with RET gene screening results in her family members in order to call attention to the diagnosis and treatment of MTC.