The efficacy and safety evaluation of 5-FU/LV and FOLFOX4 chemotherapy regimen for colorectal cancer
10.3760/cma.j.issn.1008-1372.2012.04.013
- VernacularTitle:结直肠癌术后行5-FU/LV和FOLFOX4方案化疗的疗效及安全性评价
- Author:
Guoxiong CHENG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms/surgery/drug therapy;
Antineoplastic combined chemotherapy/therapeutic use;
Protocols fluorouracil/administration & dosage;
Leucovorin/administration & dosage;
Organoplatinum compounds/administration & dosage
- From:
Journal of Chinese Physician
2012;14(4):480-482
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the efficacy and safety of two different adjuvant chemotherapy regimens of 5-FU/LV and FOLFOX4 in patients who suffered from colorectal cancer after having radical surgery.MethodsBy 123 patient who had colorectal cancer and received radical surgery from December 2005,to May 2007 were enrolled in this using retrospective analysis.68 cases received 5 FU/LV chemotherapy regimens and 35 cases received FOLFOX4 chemotherapy regimens.The results of survival rate and side effects were compared between the two groups.ResultsThe survival rates within 3 years of 5-FU/LV and FOLFOX were 77.3％ and 80％ respectively.There was no significant differences between two chemotherapy regimens ( x2 =1.26,P =0.28).The main side effects included anorexia,nausca/vomiting,alopecia and et al.However there was no significant difference in adverse reactions of two groups ( P ＞0.05 ).Conclusions5-FU/LV and FOLFOX4 were effective and safe chemotherapy regiments for patients with colorectal cancer after having radical surgery,and the side effects were acceptable in these two groups.
