Detection of HSPB1 expression in pancreatic cancer and its clinical significance
10.3760/cma.j.issn.1674-1935.2012.03.009
- VernacularTitle:热休克蛋白B1在胰腺癌组织中的表达及临床意义
- Author:
Qinghua LIU
;
Chenyan ZHAO
;
Jing ZHANG
;
Ying CHEN
;
Canrong NI
;
Minghua ZHU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasm;
Heat-shock proteins;
Microchip analytical procedures;
Immunohistoche mistry
- From:
Chinese Journal of Pancreatology
2012;12(3):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of HSPB1 in pancreatic cancer and its relationship with clinicopathological characterization.Methods Pathological specimens from 47 cases of pancreatic cancers,13 cases of para-cancerous normal pancreatic tissues and 3 cases of chronic pancreatitis tissues were selected,and tissue microarray construction instrument was used to prepare tissue microarray,then the expression of HSPB1 was determined by immunohistochemistry SP method.The scores of the proportion of positive cells and staining intensity were multiplied to make the judgment.Results The expression of HSPB1 in malignant,para-cancerous and chronic pancreatitis tissues was 80.9％ (38/47),12.5％ (2/16),respectively; and the difference between the two groups was statistically significant (X2 =24.058,P =0.000).The expression of HSPB1 in pancreatic cancer tissue was not significantly related to sex,age,location,differentiation degree and nerve infiltration of tumor ( P ＞ 0.05 ).Conclusions The expression of HSPB1 is related to development and progression of pancreatic cancer,and may be an early molecular event.
