Effect of neoadjuvant hormonal therapy in different time combined with intensity modulated radiotherapy for locally advanced prostate cancer
10.3760/cma.j.issn.1000-6702.2012.05.012
- VernacularTitle:不同时间新辅助内分泌治疗联合调强放疗对局部晚期前列腺癌疗效的影响作用
- Author:
Ruipeng HOU
;
Jian LI
;
Fengwei WANG
;
Zhihua ZHANG
;
Hao WEI
;
Tao TANG
;
Hua ZHANG
- Publication Type:Journal Article
- Keywords:
Prostatic neoplasms;
Locally advanced;
Neoadjuvant hormonal therapy;
Intensity modulated radiotherapy;
Prostate specific antigen
- From:
Chinese Journal of Urology
2012;33(5):369-372
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the ideal method of neoadjuvant hormonal therapy (NHT) for locally advanced prostate cancer.MethodsSixty cases of patients diagnosed with locally advanced ( T3 -T4 N0M0) prostate cancer were treated with NHT combined with intensity modulated radiotherapy (IMRT),They were randomly divided into 3 groups with 20 cases in each group.Group A with NHT 2 weeks,Group B with NHT 3 months,Group C with NHT 6 months.Endocrine duration began with NHT until 12 months after the end of IMRT.The PSA and prostate volumes were detected by transrectal ultrasound and Qmax was tested after NHT and every 3 months after IMRT.Results After NHT,the median PSA of different groups were decreased to 24.88,0.20 and 0.07 μg/L,respectively.There was significant difference ( P ＜ 0.05 ).The prostate volume in groups B and C reduced significantly ( P ＜ 0.05 ).The group B reduced 20.8％ and the group C reduced 39.5％.The Qmax of group B and C were ( 11.70 ± 2.81 ) and ( 14.45 ±2.61 ) ml/s respectively.After 12 months of endocrine combined with IMRT:(①)PSA.There was significant difference (P ＜0.01 ) with group C ＜ group B ＜ group A.②The prostate volume.The reducing of groups B and C were more obvious than group A ( P ＜ 0.01 ).There was no significant difference between group B and group C ( P ＞ 0.05).③Qmax.There was significant difference (P ＜ 0.01 ) among the 3 groups with group C ＞ group B ＞ group A.ConclusionsNHT combined with IMRT is an ideal method for locally advanced prostate cancer.The NHT time before IMRT treatment should last at least 3 months.
