Changes of peripheral blood lymphocyte subsets in patients with polymyositis and dermatomyositis
10.3760/cma.j.issn.1007-7480.2012.03.005
- VernacularTitle:多发性肌炎/皮肌炎患者外周血淋巴细胞亚群检测的临床应用价值
- Author:
Dongxue WANG
;
Xueying YU
;
Xiaoming SHU
;
Xiaolan TIAN
;
Ning ZU
;
Li MA
;
Guochun WANG
- Publication Type:Journal Article
- Keywords:
Polymyositis;
Dermatomyositis;
Lymphocyte subsets
- From:
Chinese Journal of Rheumatology
2012;16(3):162-166
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the clinical significance of peripheral blood lymphocyte subsets in patients with idiopathic inflammatory myopathy (ⅡM).MethodsPeripheral blood lymphocyte subsets was determined by flow cytometry in 89 patients with polymyositis(PM ) or dermatomyositis ( DM ).The association between clinical features and peripheral blood lymphocyte subsets was analyzed by F test,t test and x2 test.ResultsPatients with active DM showed significant decreases in counts of CD3+ cell,CD3+CD4+ cell and CD3+CD8+ cell[(8±4),(5.4±2.8) and (2.6±1.6) ×108/L respectively],compared with those in inactive DM [(16±6), (10.4±5.6) and (5.6±3.8) ×108/L respectively] and healthy controls [(14±4), (8.3±2.8) and (4.6±1.7) ×108/Lrespectively](F=12.901,8.257,7.084; P＜0.05).Logistic regression analysis indicated that myositis disease activity could influence the counts of peripheral blood CD3+ cell,CD3+CD4+ cell and CD3+ CD8+ cell (b=0.211,0.344,0.289; P＜0.05 ).ILD in ⅡM could influence the counts of CD3+ cell and the ratio of CD3+CD4+cell (b=0.928,1.974; P＜0.05 ).Logistic regression analysis indicated that the count of CD3+CD8+ cell was risk factor for death,and the relative risk was 0.989(b=-0.011 ; P＜0.05).ConclusionPeripheral blood lymphocyte subsets may be regarded as useful laboratory parameters for monitoring RA disease activity.Decreased CD8+ T cell may predict a poor outcome of patients with IIM.
