Research progress of additives for improving therapeutic peptides and proteins stability in PLGA microspheres
10.3760/cma.j.issn.1673-4181.2012.03.014
- VernacularTitle:提高PLGA微球载蛋白多肽类药物稳定性添加剂的研究进展
- Author:
Hongli CHEN
;
Yongxue WANG
;
Weiyun GUO
;
Qiqing ZHANG
- Publication Type:Journal Article
- Keywords:
Poly-lactic-co-glycolic acid microspheres;
Additive;
Stability;
Therapeutic peptides and proteins
- From:
International Journal of Biomedical Engineering
2012;35(3):185-188
- CountryChina
- Language:Chinese
-
Abstract:
Microspheres made of poly-lactic-co-glycolic acid (PLGA) have been frequently proposed as drug delivery systems.A very significant challenge in the development of controlled PLGA releasing systems is the instability of drugs especially therapeutic peptides and proteins.Additional approaches,particularly the use of additives,are needed to optimize PLGA delivery of drugs.This article reviews the effects of additives,especially the effects of stabilizing protein during the preparation of PLGA microsphere and the sustained drug releasing processes.
